Back in 1993, when drugmaker Amarin's (NASDAQ:AMRN) shares first hit the market, it might have cost you $1,425 to buy one share (adjusted for splits). Go forward a few decades, and that one share now costs a little over $5. Clean Energy Fuels (NASDAQ:CLNE) , meanwhile, hit its high-water mark in 2012, with the share price almost touching $25. Now the stock has lost 90% of its value, and currently trades for $2.50.

Yet there is reason to be optimistic about both companies. Read on to see why you might want to buy these shares at rock-bottom prices.

One-quarter of all adult Americans have high triglycerides. If you're one of them, it means you have too many fats (lipids) in your bloodstream. This is an unhealthy state of affairs that raises the risk of heart damage.

Amarin's pill, Vascepa, reduces triglyceride levels. Several years ago, the company wanted to market this drug as helpful to reducing the risk of heart attack or stroke. But the FDA's response was the equivalent of "Not so fast; there's no evidence that reducing triglycerides does all that. You're going to have to prove it."

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