Two of the three COVID-19 vaccines available in the U.S. right now require two doses spaced several weeks apart. But could Americans ultimately need a third vaccine shot? In this Motley Fool Live video recorded on March 3, 2021, Fool.com contributors Keith Speights and Brian Orelli discuss how new coronavirus variants could increase the likelihood that another booster shot will be required.

Keith Speights: Pfizer(NYSE:PFE) and BioNTech(NASDAQ:BNTX) announced last week that they are testing a third vaccine shot as a booster. What they're doing is they're trying to see if they could increase protection against the new coronavirus variants. The companies are also talking with the FDA and other regulatory authorities about potentially conducting yet another clinical study to evaluate a version of their vaccine BNT162b2, to specifically target that variant that was first identified in South Africa, it's called B.1.351.

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