(CNN)He's undecided on the nominee to head Health and Human Services. He's not sure if he'll back the No. 3 for the Justice Department, or the undersecretary of policy at the Pentagon.

He says maintaining the 60 vote-requirement to overcome a filibuster is a "red line" for him. And he's made clear he'll block advancing an infrastructure package on a party-line vote if Democrats don't work with Republicans.

In a 50-50 Senate, with most members voting the party-line, Sen. Joe Manchin stands mostly alone: effectively holding veto power over many of President Joe Biden's nominees and key elements of his agenda.

"It's a shame," Manchin, a Democrat from West Virginia, told CNN when asked about his newfound veto power. "There are 49 other Democrats. Please come forward."

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