NAIROBI, Kenya — The second-worst Ebola outbreak in history is over, the World Health Organization said on Thursday, after nearly two years and 2,280 deaths.

Efforts to fight the outbreak in eastern Congo were hampered by mistrust from community members, feuds between government officials, attacks on health care facilities and the emergence of new hot spots. The announcement came even as the country contended with the world’s largest measles epidemic as well as the coronavirus pandemic.

The response drew on 16,000 front-line workers, technological innovation and a new vaccine. Ebola, a hemorrhagic fever that is transmitted through contact with sick or dead people or animals, causes fever, bleeding, weakness and abdominal pain. The average fatality rate is about half.

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