April 19, 2021 -- Transgender people treated with gender-affirming hormone therapy show distinctive changes in blood pressure that begin soon after treatment starts and do not ease over years of treatment, according to the largest and longest observational study to look at the issue.

"Many physicians may not be aware of the changes to blood pressure in trans patients who start hormone therapy," senior author Michael S. Irwig, MD, director of transgender medicine at Beth Israel Deaconess Medical Center in Boston, told Medscape.

"The take-away message for physicians is to monitor blood pressure both before and after starting hormone therapy in transgender patients, as over a third of transgender individuals had stage 1 hypertension before starting hormone therapy, and many had their blood pressure increase after starting hormone therapy."

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