Heads up, vape nation: there’s a chance that ripping some fat nicotine-infused clouds could end up giving you cancer.

In a landmark study funded by the National Institutes of Health, researchers at New York University found that e-cigarette vapor causes lung cancer and maybe even bladder cancer in mice, as CNBC reports. It’s the first time a study has found concrete links between nicotine vaping products and cancer.

“It’s foreseeable that if you smoke e-cigarettes, all kinds of disease comes out” over time, lead researcher Moon-Shong Tang told CNBC. “Long term, some cancer will come out, probably. E-cigarettes are bad news.”

The study was published Monday in the prestigious journal Proceedings of the National Academy of Sciences.

Intriguingly, the results could be good news for THC vapers. Nine out of 40 mice exposed to nicotine e-cig vapor developed lung cancer — but zero out 20 mice exposed to e-cig vapor without nicotine developed cancer.

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