About 50,000 people will run the New York City marathon on Nov. 3. Our eyes will be on one guy in particular, Yasir Salem. In 2018, after that same marathon, he set out to race 50 marathons in 50 states. Not just because he’s an extreme athlete who can. But because he’s doing this “50-in-50” effort to raise awareness for the Gweneviere Mann Foundation, which is dedicated to helping more people who need it get screened for lung and brain cancers earlier. And because Gweneviere Mann was his running partner. And wife.

The couple ran their first marathon together—New York’s—in 2010, a year after Gweneviere recovered from surgery to remove a meningioma tumor in her brain. In the eight years after that, Yasir and Gwen ran eight marathons together. In the summer of 2018, Gweneviere was diagnosed with a rare form of lung cancer that she couldn’t beat.

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